R. Baurain

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.

A. Trouet, Michèle Masquelier, R. Baurain et al. · Proceedings of the National Academy of Sciences · 1982 · 233 citations

Medicine, Oncology, Pharmacology +16

Amino acid and dipeptide derivatives of daunorubicin. 1. Synthesis, physicochemical properties, and lysosomal digestion

Michèle Masquelier, R. Baurain, André Trouet · Journal of Medicinal Chemistry · 1980 · 70 citations

Life Sciences, Biochemistry, Pharmacology +11

Extracellularly tumor-activated prodrugs for the selective chemotherapy of cancer: application to doxorubicin and preliminary in vitro and in vivo studies.

André Trouet, A. Passioukov, Kim Van derpoorten et al. · PubMed · 2001 · 68 citations

Medicine, Oncology, Pharmacology +16

Amino acid and dipeptide derivatives of daunorubicin. 2. Cellular pharmacology and antitumor activity of L1210 leukemic cells in vitro and in vivo

R. Baurain, Michèle Masquelier, D. Deprez-De Campeneere et al. · Journal of Medicinal Chemistry · 1980 · 57 citations

Medicine, Medicinal Chemistry, Pharmacology +6

Cellular uptake and metabolism of daunorubicin as determined by high-performance liquid chromatogaphy

R. Baurain, A. Zenebergh, André Trouet · Journal of Chromatography A · 1978 · 47 citations

Medicine, Pharmacokinetics, Pharmacology +11