Gut Hormones as Mediators of Appetite and Weight Loss After Roux-en-Y Gastric Bypass

Abstract

The attenuated appetite after gastric bypass is associated with elevated PYY and GLP-1 concentrations, and appetite returns when the release of gut hormones is inhibited. The results suggest a role for gut hormones in the mechanism of weight loss after gastric bypass and may have implications for the treatment of obesity.