The Journal of Experimental Medicine · 1987 · 230 citations · 12 references
Veterinary MedicineImmunologyInfectious DiseasesImmunizationParasite ImmunologyVaccinologyAntigen DesignMalariaProtozoan ImmunologySubunit VaccinesToxoid VaccinesVaccine Antigen DesignMalaria ParasitesMalaria ProphylaxisMalaria VaccinesParasite VaccinesSporozoite AntigensSynthetic VaccineTetanus Toxoid VaccineVaccine Candidate Antigens
A synthetic peptide, (DPPPPNPN)2D, representing a subunit of the repeat domain of the Plasmodium berghei circumsporozoite protein, was conjugated to tetanus toxoid using bisdiazobenzidine. Immunization of mice and rats with the conjugate induced high serum titers of antibodies to the parasite, and most of the animals were completely protected from malaria infection when challenged with sporozoites.
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