cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.

Abstract

-9-[2-hydroxy-3-nonyl]adenine) is a wellknown inhibitor of adenosine deaminase. Recently, EHNA was shown to block the activity of purified soluble cGMPstimulated phosphodiesterase (PDE2) from frog, human, and porcine heart with an apparent K i value of 1 M and with negligible effects on Ca 2 /calmodulin PDE (PDE1), cGMP-inhibited PDE (PDE3), and low K m cAMP-specific PDE (PDE4) (