Histopathological evaluation of bone tumors in a tertiary care hospital in Manipur, India

Abstract

Objective: To determine the spectrum of various bone tumors and their relative frequency at Regional Institute of Medical Sciences (RIMS) Hospital. Materials and Methods: A retrospective review of histopathological reports of all bone specimens received in the Department of Pathology (histopathology section), RIMS hospital for a period of 2 years from January 2009-December 2011 was done. Results: Of the 98 histopathologically diagnosed bone lesions, 50 (51%) were males and 48 (49%) were females, with a male to female ratio of 1.04:1. Age ranged from 7-74 years. Nonneoplastic lesions accounted for 36.7%, while neoplastic lesions accounted for 63.3%. Osteomyelitis was the most common and only nonneoplastic lesion encountered with 36 cases (36.7%). Out of 62 cases of bone tumors, benign tumors made up to 66.01%, while the malignant tumor and tumor-like lesions made up 17.71 and 16.2%, respectively. Age ranged from 8-74 years, in which 34 (55%) were males and 28 (45%) were females with M:F ratio of 1.2:1. Osteochondroma with 22 cases (35.2%) and osteosarcoma with seven cases (11.27%) were the most common benign and malignant tumors, respectively; while fibrous dysplasia with five cases (8.05%) was the most common tumor-like lesion. The age peak incidence was in the 2 nd (43.55%) and 3 rd (32.2%) decades. Femur was the most common site with 19 (30.6%) occurrences followed by tibia with 18 (29%). Conclusion: Chronic osteomyelitis was the commonest nonneoplastic lesion. Among the bone tumors, osteochondroma and osteosarcoma was the most common benign and malignant bone tumor, respectively.