Effects of Somatostatin and Octreotide on the Interactions between Neoplastic Gastroenteropancreatic Endocrine Cells and Endothelial Cells: A Comparison between in vitro and in vivo Properties

Abstract

The in vitro antiangiogenic effects of somatostatin and its analogues are likely to be efficiently counterbalanced in the tumor microenvironment by the concomitant release of proangiogenic factors like VEGF.