Decreased plasma orexin-A levels in obese individuals

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.4K citations

Life Sciences, Genetics, Molecular Genetics +12

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li et al. · Cell · 1999 · 2.6K citations · Full text

Medicine, Neurology, Neuroscience +13

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

Tamás L. Horváth, Sabrina Diano, Anthony N. van den Pol · Journal of Neuroscience · 1999 · 505 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels¹

David S. Weigle, P. Barton Duell, William E. Connor et al. · The Journal of Clinical Endocrinology & Metabolism · 1997 · 392 citations · Full text

Life Sciences, Nutritional Sciences, Physiology +12