Upregulation of Transforming Growth Factor‐β1 and Vascular Endothelial Growth Factor Gene and Protein Expression in Cyclosporin‐Induced Overgrown Edentulous Gingiva in Rats

Abstract

Greater mRNA expression and positive staining for TGF-beta1 and VEGF were observed in the edentulous gingivae of rats that received CsA. Therefore, CsA may upregulate TGF-beta1 and VEGF gene expression and protein secretion in CsA-induced gingival overgrowth.