Single-cell screening of cytosolic [Ca2+] reveals cell-selective action by the Alzheimer’s Aβ peptide ion channel

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

MP Mattson, Bin Cheng, David L. Davis et al. · Journal of Neuroscience · 1992 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

Angelo Demuro, Erene Mina, Rakez Kayed et al. · Journal of Biological Chemistry · 2005 · 1K citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

Hai Lin, Rajinder Bhatia, Ratneshwar Lal · The FASEB Journal · 2001 · 642 citations

Life Sciences, Neurobiology, Neuroscience +17

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

Kishore V. Kuchibhotla, Samuel T. Goldman, Carli Lattarulo et al. · Neuron · 2008 · 623 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

Nelson Arispe, Harvey B. Pollard, Emilio Rojas · Proceedings of the National Academy of Sciences · 1993 · 554 citations

Life Sciences, Biochemistry, Neuroscience +17