Clinical and experimental hypertension · 1980 · 91 citations · 23 references
MedicineCardiologyPharmacologyCardiovascular PharmacotherapyPreventive CardiologyRenal PharmacotherapyBlood Pressure ControlBlood Pressure ManagementCardiac MedicationsHypertension ControlHypertension PharmacotherapyHypertension PreventionAntihypertensive PharmacologyCaptopril TherapyHeart RatePlasma Renin ActivityRenin-angiotensin System InhibitorsRenin-angiotensin System ModulationRenin-angiotensin-aldosterone System InhibitionRenin-angiotensin-aldosterone System Inhibitors
Captopril (100mg/kg) administered daily by gavage to young spontaneously hypertensive rats (SHRs) from their 6th to 20th weeks of age almost completely inhibited genetic hypertension development (GHD). This effect was correlated with an early and long-lasting limitation of the progressive increase in peripheral resistance which normally develops in SHRs during their growth. Heart rate, cardiac and systolic indexes remained unchanged, plasma renin concentration was significantly increased and heart weight/body weight ratio was significantly decreased. At last, captopril's GHD preventive effect persisted up to 12 weeks after treatment discontinuation.
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Cardiac Hypertrophy in Spontaneously Hypertensive Rats
Subha Sen, Robert C. Tarazi, Philip A. Khairallah et al. · Circulation Research · 1974 · 459 citations · Full text