Nanotechnology · 2005 · 70 citations · 12 references
PharmacyPharmaceutical BiotechnologyPharmaceuticsBioavailabilityDrug DeliveryNanoparticle Drug DeliveryDrug EncapsulationDrug SolubilityNanoparticle Delivery SystemsNanoparticle DesignNanoparticle FormulationsSolubility EnhancementNanoparticle PharmacologyNanoparticle-mediated Bioavailability EnhancementNanoparticlesPoorly Soluble Drug FormulationPoorly Water-soluble Drugs
Nanosizing of poorly water soluble drugs or incorporating them into nanoparticles to increase their solubility and thereby the bioavailability has become a favoured approach today. This work describes a novel method for encapsulating poorly water soluble phytochemical ellagic acid that is also sparingly soluble/insoluble in routine solvents used to prepare nanoparticles.
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Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah et al. · Pharmaceutical Research · 1995 · 5.3K citations · Full text