Transplantation · 2010 · 70 citations · 11 references
MedicineCell BiologySurgeryCell TherapyRegenerative MedicineStem Cell TransplantationCell EngraftmentGraft SurvivalMesenchymal Stem Cell TherapyMesenchymal Stromal Cell TherapyTransplant OutcomesTransplant SurvivalClinical Trial Efficacy EndpointsEfficacy Endpoints ValidationMesenchymal Stem Cell EngraftmentMesenchymal Stromal Cell Clinical TrialsMesenchymal Stromal Cell EngraftmentMesenchymal Stromal Cell SafetyPrimary Efficacy EndpointsSecondary Efficacy Endpoints
There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.
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