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Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes

Masao Honda, Takayoshi Shirasaki, Tetsuro Shimakami, Akito Sakai, Rika Horii, Kuniaki Arai, Tatsuya Yamashita, Yoshio Sakai, Taro Yamashita, Hikari Okada,

Hepatology · 2014 · 39 citations · 20 references

DOIFull text

Open access

Abstract

Immune cells were lost and induced the expression of other inflammatory mediators, such as WNT5A, in the liver of IL28B minor genotype patients. This might be related to the high level of hepatic ISG expression in these patients and the treatment-resistant phenotype of the IL28B minor genotype.

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