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IDENTIFICATION OF PERITONEAL MACROPHAGES IN MOUSE RADIATION CHIMERAS
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1963
Year
Cell TherapyRadiation EffectImmunologyRadiation ExposurePathologyExperimental PathologyRadiation BiologyImmunotherapyDonor-type MacrophagesHematologySpecific IsoantiseraCell TransplantationRadiation OncologyHealth SciencesXenotransplantationHistopathologyCell BiologyPhagocytePathogenesisMouse Radiation ChimerasGeneral PathologyMedicine
Using the cytotoxic activity of specific isoantisera it was found that free peritoneal macrophages of mouse radiation chimeras are completely replaced by donor-type macrophages about 6 weeks after irradiation and administration of homologous bone marrow. Possible implications regarding the genotype of the fixed reticuloendothelial cells of chimeras are discussed.