Concepedia

Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1α

Keiichiro Matoba, Daiji Kawanami, Rina Okada, Masami Tsukamoto, Jun Kinoshita, Tomoko Ito, Sho Ishizawa, Yasushi Kanazawa, Tamotsu Yokota, Noriyuki Murai,

Kidney International · 2013 · 97 citations · 39 references

DOI

Concepts

References

39

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

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HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Edurne Berra · The EMBO Journal · 2003 · 1.3K citations · Full text

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Nephropathy in Diabetes

Diabetes Care · 2004 · 1K citations

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Debra F. Higgins, Kuniko Kimura, Wanja M. Bernhardt et al. · Journal of Clinical Investigation · 2007 · 967 citations · Full text

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Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

Wenjian Wang, Yin Wang, Jianyin Long et al. · Cell Metabolism · 2012 · 471 citations · Full text

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