CHARACTERISTICS OF IMMUNOGLOBULIN GENE USAGE OF THE XENOANTIBODY BINDING TO GAL-??(1,3)GAL TARGET ANTIGENS IN THE GAL KNOCKOUT MOUSE1

Abstract

These results demonstrate the similarity of the Gal o/o mice and humans in their immune response to galalpha(1,3)gal epitopes. Gal o/o mouse can serve as a useful model for examining the genetic control of antibody/antigen interactions associated with the humoral response to pig xenografts in humans.