Concepedia

A New Monitoring Protocol for Clozapine-Induced Myocarditis Based on an Analysis of 75 Cases and 94 Controls

Kathlyn J. Ronaldson, Paul B. Fitzgerald, Andrew J. Taylor, Duncan J. Topliss, John J. McNeil

Australian & New Zealand Journal of Psychiatry · 2011 · 228 citations · 9 references

DOI

Abstract

This protocol recommends active monitoring for 4 weeks, relying predominantly on troponin and C-reactive protein results. It encourages continuation of clozapine in the presence of mild illness, but defines a threshold for cessation.

References

9

11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)

Jari Tiihonen, Jouko Lönnqvist, Kristian Wahlbeck et al. · The Lancet · 2009 · 1.3K citations

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Myocarditis and cardiomyopathy associated with clozapine

Jens Kilian, K. M. Kerr, Christopher Lawrence et al. · The Lancet · 1999 · 543 citations

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Diagnostic Characteristics of Clozapine-Induced Myocarditis Identified by an Analysis of 38 Cases and 47 Controls

Kathlyn J. Ronaldson, Andrew J. Taylor, Paul B. Fitzgerald et al. · The Journal of Clinical Psychiatry · 2010 · 150 citations

Clinical course and analysis of ten fatal cases of clozapine-induced myocarditis and comparison with 66 surviving cases

Kathlyn J. Ronaldson, Paul B. Fitzgerald, Andrew J. Taylor et al. · Schizophrenia Research · 2011 · 96 citations

, , +1

Cardiomyopathy Associated with Clozapine

Raphael J. Leo, Joy L Kreeger, Kye Y. Kim et al. · Annals of Pharmacotherapy · 1996 · 56 citations