Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

Carolyn F. Deacon, Anders H. Johnsen, Jens J. Holst · The Journal of Clinical Endocrinology & Metabolism · 1995 · 757 citations

Life Sciences, Biochemistry, Endocrinology +16

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

Carolyn F. Deacon, Michael A. Nauck, M. Toft-Nielsen et al. · Diabetes · 1995 · 716 citations

Medicine, Endocrinology, Pharmacokinetics +7

Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration

Lotte Bjerre Knudsen, Per F. Nielsen, Per Olaf Huusfeldt et al. · Journal of Medicinal Chemistry · 2000 · 687 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Allylic protecting groups and their use in a complex environment part II: Allylic protecting groups and their removal through catalytic palladium π-allyl methodology

François Guibé · Tetrahedron · 1998 · 286 citations

Natural Sciences, Chemical Engineering, Chemistry +14

Structure-activity studies of glucagon-like peptide-1.

Kim Adelhorst, B.B. Hedegaard, Lotte Bjerre Knudsen et al. · Journal of Biological Chemistry · 1994 · 282 citations · Full text

Medicine, Biochemistry, Pharmacology +17