Histoplasma Endocarditis Cured with Amphotericin

Abstract

ENDOCARDITIS due to fungi is a rare disease and one in which little success has been achieved in therapy. Seventeen cases of endocarditis due to Histoplasma capsulatum have been reported,1 2 3 4 5 6 7 and in the main the diagnoses have been made on post-mortem examination. Only one case has been reported as cured with antimicrobial therapy.1 The purpose of this paper is to report a case of histoplasma endocarditis in which the diagnosis was first suggested by microscopical examination of tissue removed at femoral embolectomy. Confirmatory evidence was obtained with serum complement-fixation tests and by examination of the tissue with fluorescent-antibody staining. The . . .