FUNGAL ENDOCARDITIS: REVIEW OF THE LITERATURE AND REPORT OF THREE CASES

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Article1 February 1958FUNGAL ENDOCARDITIS: REVIEW OF THE LITERATURE AND REPORT OF THREE CASESRICHARD K. MERCHANT, M.D., DONALD B. LOURIA, M.D., PHILIP H. GEISLER, M.D., JOHN H. EDGCOMB, M.D., JOHN P. UTZ, M.D.RICHARD K. MERCHANT, M.D., DONALD B. LOURIA, M.D., PHILIP H. GEISLER, M.D., JOHN H. EDGCOMB, M.D., JOHN P. UTZ, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-2-242 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONEndocardial involvement in fungal disease is uncommon. Its true incidence has been obscured by confusion in terminology by both clinicians and bacteriologists. According to commonly accepted methods of classification,1, 2the higher fungi (Eumycetes) are separated from the bacteria (Schizomycetes). To the latter category belong not only the common bacteria but also the so-called higher bacteria, including, among others, the following organisms which have been implicated in endocarditis:3-5Actinomyces bovis, Actinomyces graminis, Actinomyces septicus, Nocardia asteroides, Leptothrix, Streptobacillus moniliformis(which is also calledStreptothrixandActinomyces muris),Erysipelothrix rhusiopathiae, diphtheroids,Listeria monocytogenes, andActinobacillus lignieresi. Since none of these...Bibliography1. ConantSmithBakerCallawayMartin NFDTRDJLDS: Manual of clinical mycology, 2nd Ed., 1954, W. B. Saunders Co., Philadelphia, p. 381. Google Scholar2. Simons RD: Medical mycology, 1954, Alsevier Publishing Co., Amsterdam, p. 11. Google Scholar3. Jones M: Subacute bacterial endocarditis of non-streptococcal etiology, Am. Heart J. 40: 106-116, 1950. CrossrefMedlineGoogle Scholar4. BeamerReinhardGoodof PREHII: Vegetative endocarditis caused by higher bacteria and fungi, Am. Heart J. 29: 99-112, 1945. CrossrefGoogle Scholar5. HoeprichChernoff PDHM: Subacute bacterial endocarditis due to Listeria monocytogenes , Am. J. Med. 19: 488-494, 1955. CrossrefMedlineGoogle Scholar6. JoachimPolayes HSH: Subacute endocarditis and systemic mycosis (Monilia), J. A. M. A. 115: 205-208, 1940. CrossrefGoogle Scholar7. WiklerWilliamsDouglassEmmonsDunn AEGEDCWRC: Mycotic endocarditis: report of a case, J. A. M. A. 119: 333-336, 1942. CrossrefGoogle Scholar8. Pasternack JG: Subacute monilia endocarditis: new clinical and pathological entity, Am. J. Clin. Path. 12: 496-505, 1942. CrossrefGoogle Scholar9. GeigerWennerAxilrodDurlacher AJHAHDSH: Mycotic endocarditis and meningitis: report of case due to Monilia albicans , Yale J. Biol. and Med. 18: 259-268, 1946. MedlineGoogle Scholar10. Zimmerman LE: Candida and aspergillus endocarditis, with comments on the role of antibiotics in dissemination of fungus disease, Arch. Path. 50: 591-605, 1950. MedlineGoogle Scholar11. WolfeHenderson EIFW: Mycotic endocarditis: report of a case, J. A. M. A. 147: 1344-1346, 1951. CrossrefMedlineGoogle Scholar12. KunstadterMacLeanGreengard RHHJ: Mycotic endocarditis due to C. albicans , J. A. M. A. 149: 829-832, 1952. CrossrefMedlineGoogle Scholar13. Niel K(a) : Zur Klinik der Candidainfektionen, Klin. med. 8: 49-54, 1953. (b) Köhlmeier, W.: Zur Kenntnis der Candidainfektionen, Klin. med. 8: 54-61, 1953. Google Scholar14. Caplan H: Monilia (Candida) endocarditis following treatment with antibiotics, Lancet 2: 957-958, 1955. CrossrefGoogle Scholar15. KoellePastor WABH: Candida albicans endocarditis after aortic valvulotomy, New England J. Med. 255: 997-999, 1956. CrossrefMedlineGoogle Scholar16. Hurley TD: A unique lesion of the heart in systemic blastomycosis, J. Med. Research 33: 499-502, 1915. Google Scholar17. BakerBrian RDEW(a) : Blastomycosis of the heart, Am. J. Path. 13: 139-147, 1937. (b) Martin, D. S., and Smith, D. T.: Blastomycosis, Am. Rev. Tuberc. 39: 488-515, 1939. MedlineGoogle Scholar18. PondHumphreys NERJ: Blastomycosis with cardiac involvement and peripheral embolization, Am. Heart J. 43: 615-620, 1952. CrossrefMedlineGoogle Scholar19. Epstein E: Prognostic significance of cutaneous lesions in coccidioidal granuloma, Arch. Dermat. and Syph. 38: 752-755, 1938. CrossrefGoogle Scholar20. Cawley EP: Aspergillosis and the aspergilli: report of a unique case of the disease, Arch. Int. Med. 80: 423-434, 1947. CrossrefGoogle Scholar21. WelshBuchness RAJM: Aspergillus endocarditis, myocarditis, and lung abscess: report of a case, Am. J. Clin. Path. 25: 782-786, 1955. CrossrefMedlineGoogle Scholar22. KirschsteinSidransky RLH: Mycotic endocarditis of the tricuspid valve due to Aspergillus flavus: report of a case, Arch. Path. 62: 103-106, 1956. MedlineGoogle Scholar23. LombardoRabsonDodge TAASHT: Mycotic endocarditis: report of a case due to Cryptococcus neoformans , Am. J. Med. 22: 664-670, 1957. CrossrefMedlineGoogle Scholar24. BrodersDochatHerrellVaughn ACGRWELD: Histoplasmosis producing vegetative endocarditis, J. A. M. A. 122: 489-492, 1943. CrossrefGoogle Scholar25. KemperBloom JWHJ: Histoplasmosis: report of a case, J. Oral Surg. 2: 167-172, 1944. Google Scholar26. ParsonsZarafonetis RJCJ: Histoplasmosis in man, Arch. Int. Med. 75: 1-23, 1945. CrossrefGoogle Scholar27. FawellBrownsErnstene WNHLAC: Vegetative endocarditis due to Histoplasma capsulatum , Cleveland Clin. Quart. 18: 305-309, 1951. CrossrefGoogle Scholar28. Binford CH(a) : Histoplasmosis: tissue reactions and morphologic variations of the fungus, Am. J. Clin. Path. 25: 25-36, 1955. (b) Binford, C. H.: Personal communication. CrossrefMedlineGoogle Scholar29. Zimmerman LE: Some contributions of the histopathological method to the study of fungus disease, Tr. New York Acad. Sc. 19: 358-371, 1957. CrossrefMedlineGoogle Scholar30. Sulack MH, in Clinicopathologic conference, U. S. Armed Forces M. J. 8: 70-81, 1957. Google Scholar31. Moore M: Morphologic variation in tissue of organisms of the blastomycoses and of histoplasmosis, Am. J. Path. 31: 1049-1063, 1955, quoting unpublished case of Dominguez, R., and Golden, A. MedlineGoogle Scholar32. Torack RM: Fungus infections associated with antibiotic and steroid therapy, Am. J. Med. 22: 872-882, 1957. CrossrefMedlineGoogle Scholar33. LewisonJackson MH: A case of systemic blastomycosis, Arch. Int. Med. 13: 575-584, 1914. CrossrefGoogle Scholar34. FriedmanDonaldson NBL: Systemic mycosis with mycotic endocarditis, Arch. Path. 27: 394, 1939. Google Scholar35. Humphrey AA: Reticuloendothelial cytomycosis (histoplasmosis of Darling), Arch. Int. Med. 65: 902-918, 1940. CrossrefGoogle Scholar36. SacksAta IG: Subacute bacterial endocarditis from infection by Monilia albicans , S. African M. J. 15: 456-458, 1941. Google Scholar37. CasselsSteiner DP: Mycotic endocarditis: report of case with necropsy: review of the literature, Am. J. Dis. Child. 67: 128-138, 1944. CrossrefGoogle Scholar38. Luttgens WF: Endocarditis in "main line" opium addicts: report of 11 cases, Arch. Int. Med. 83: 653-664, 1949. CrossrefGoogle Scholar39. PeelerRiley MBHD: Cardiac tamponade due to swallowed foreign body, Am. J. Dis. Child. 93: 308-312, 1957. Google Scholar40. PaplanusCate SWR: Monilia endocarditis due to foreign body in heart, unpublished, as referred to by Peeler and Riley.39 Google Scholar41. DickMullin HJEW: Myxoma of heart complicated by bloodstream infection of Staphylococcus aureus and Candida parapsilosis , New York State J. Med. 56: 856-859, 1956. MedlineGoogle Scholar42. Zimmerman LE: Fatal fungus infections complicating other diseases, Am. J. Clin. Path. 25: 46-65, 1955. CrossrefMedlineGoogle Scholar43. SternbergWrightOura THETM: A new antifungal antibiotic, Amphotericin B, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, pp. 566-573. Google Scholar44. SteinbergJamborSuydam BAWPLO: Amphotericins A and B: two new antifungal antibiotics possessing high activity against deep-seated and superficial mycoses, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, pp. 574-578. Google Scholar45. LouriaFederEmmons DBNCW: Amphotericin B in experimental histoplasmosis and cryptococcosis, in Antibiotics annual 1956-1957, 1957, Medical Encyclopedia, Inc., New York, pp. 870-877. Google Scholar46. BaumRubelSchwarz CLHJ: Treatment of experimental histoplasmosis, in Antibiotics annual 1955-1956, 1956, Medical Encyclopedia, Inc., New York, pp. 878-882. Google Scholar47. LouriaMitchellFeder DBWN: Factors influencing the isolation of fungal pathogens, to be published. Google Scholar48. Louria DB: Some aspects of absorption, distribution and excretion of the amphotericins, to be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication August 6, 1957.From the Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.Requests for reprints should be addressed to John P. Utz, M.D., Chief, Infectious Disease Service, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda 14, Maryland.†National Cancer Institute. 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