Publication | Closed Access
Total Synthesis of Iejimalide B. An Application of the Shiina Macrolactonization
34
Citations
36
References
2007
Year
Medicinal ChemistryJulia OlefinationsBioorganic ChemistryShiina MacrolactonizationNatural SciencesMedicineIejimalide BTotal SynthesisOrganic ChemistryChemistryHeterocycle ChemistryPharmacologySynthetic ChemistryEnantioselective SynthesisDrug DiscoveryNatural Product Synthesis
The potent anticancer compound iejimalide B (1) was prepared by a total synthesis through a strategy that features Julia olefinations, Wittig olefinations, a Carreira enantioselective alkynylation, a Heck reaction, a Marshall propargylation reaction, a Stille coupling, and a Shiina macrolactonization.
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