Carcinogenesis · 1984 · 21 citations · 0 references
Life SciencesBiochemistryPhysiologyCellular MetabolismMetabolismRedox BiochemistryOxidative MetabolismOxygen EffectReactive Nitrogen Species BiologyReactive Oxygen SpeciesReactive Oxygen Species BiologyNitrate MetabolismNitrate PathwayNitric OxideNitric Oxide MetabolismOxidationSuperoxide Dismutase FunctionXanthine Oxidoreductase Metabolism
The oxidation of NH3 to NO3- by rat liver in vitro is described. A xanthine-xanthine oxidase reaction also oxidized NH3 to NO3- when H2O2 was added. An in vivo inhibitor of superoxide dismutase enhanced the in vitro liver conversion of NH3 to NO3-. Thus, intracellular oxidation by activated oxygen likely represents the source of endogenously formed NO3- in mammals.