Preliminary Observations of the Effects on Breast Adenocarcinoma of Plasma Perfused over Immobilized Protein A

Abstract

PROTEIN A, a constituent of the cell wall of Staphylococcus aureus Cowans 1 (SpA), reacts with the Fc region of immunoglobulins from many mammalian species and combines with immune complexes in serum.1 2 3 4 Previously, tumoricidal effects were observed in a patient with cancer of the colon after administration of autologous plasma that had been circulated over immobilized SpA.5 This approach was extended to dogs with spontaneous breast adenocarcinoma, and rapid and extensive tumor necrolytic reactions were noted after plasma perfusion over SpA but not over protein A-deficient staphylococcus.6 , 7 These findings were confirmed in an independent study.8 Similar tumor necrolytic responses were . . .