AIDS Research and Human Retroviruses · 2004 · 38 citations · 19 references
MedicineInfectious DiseasesPharmacologyHepatic PharmacokineticsHepatotoxicologyVirologyAntiretroviral TherapyAntiviral PharmacologyAntiviral PharmacotherapyAntiviral TherapyLiver DiseaseViral HepatitisAntiretroviral ToxicityAntiviral Safety AssessmentAntiviral ToxicologyHepatic Toxicity Of AntiretroviralsHepatitis C InfectionLiver Toxicity AssessmentTreatment In Coinfected Patients
Liver toxicity is a common side effect of antiretroviral therapy, particularly in subjects coinfected with the hepatitis C virus (HCV). The incidence of severe liver toxicity after initiation of treatment with lopinavir (LPV) as well as its possible association with LPV plasma levels were assessed in 120 HIV-infected patients (52% coinfected by HCV). The incidence of severe liver toxicity at 3 months was 1.7% and the cumulative incidence at 12 months was 4%. The development of severe liver toxicity was associated with HCV coinfection but not with LPV plasma levels.
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