ASAIO Journal · 1977 · 12 citations · 0 references
MedicineHematologyNephrologyDialysisHemodialysisRenal Replacement TherapyAnticoagulation In HemodialysisAnticoagulation In Kidney DiseaseChronic HemodialysisChronic Kidney DiseaseDialysate CompositionPlatelet PhysiologyAnticoagulation In Dialysis PatientsAnticoagulation In Kidney TransplantationBioactivity AssessmentBleeding Risk ReductionHeparin AnticoagulationHeparin-mediated AnticoagulationUremic Bleeding
1. A totally heparin grafted dialysis system shows great promise in the treatment of chronic uremia associated with bleeding risk. 2. Long-term treatment of chronic uremia with this system has to await: a) Further studies of the chronic toxicity of CPC. b) Evaluation of performance which may be achieved by using a more homogeneous heparin with higher bioactivity. 3. Detailed studies of platelet factor 4 release with subsequent heparin neutralization to determine the importance of this variable in its effect on system performance.