MedChemComm · 2014 · 60 citations · 74 references
MedicineMedicinal ChemistryPharmacologyApoptosisCancer PharmacologyDrug DiscoveryApoptosis PharmacologyCytotoxic ChemotherapyMicrotubule Assembly InhibitionMicrotubule-targeting AgentsMitotic InhibitorsAnticancer ActivityAnticancer ChemotherapyAntimitotic ChemotherapyAntimitotic DrugsMicrotubule Polymerization InhibitionPyrazine ChemistrySynthetic Microtubule-targeting AgentsTubulin Polymerization Inhibitors
Novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines that exhibit potent tubulin polymerization inhibition, anticancer activity, anti-migration of cancer cells, chromosomal damage, and apoptosis have been developed.
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Development and testing of a general amber force field
Junmei Wang, Romain M. Wolf, James W. Caldwell et al. · Journal of Computational Chemistry · 2004 · 19.6K citations