Experimental Biology and Medicine · 1950 · 32 citations · 0 references
MedicinePharmacologyToxicologyRadiation DosimetryRadiation ProtectionRadiobiologyBiological Effects Of RadiationHigh-dose Radiation EffectsRadiation PhysiologyRadiation TherapyRadiation ToxicityTotal Body IrradiationMethemoglobin FormationPre-treatmentProtective TreatmentsRadiation Dose EffectsRadiation ToxicologyRadioprotective EffectsRadiotoxicitySurvival Rates
Para-aminopropiophenone (PAPP) when injected intraperitoneally in mice produces a maximum methemoglobinemia in 30 minutes with only a slight decrease in the methemoglobin level after 60 minutes. Of 180 mice given a single exposure of 800 r total-body X-radiation 100% of 60 controls died within 30 days. Pre-treatment of groups of the remaining 120 mice with PAPP in doses of 20, 30, 40, and 50 mg/kg, 30 minutes before X-ray exposure, resulted in 30-day survival rates of 45, 50, 60, and 72.5%, respectively. Injection of 50 mg/kg of PAPP after irradiation did not affect mortality. In a preliminary test pre-treatment with PAPP also reduced the 30-day mortality in rats exposed to X-radiation.