Effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats

Handbook of Physiology.

F. Plum · Archives of Neurology · 1960 · 10.4K citations

Peripheral Nervous System, Integrative Physiology, Muscle Physiology +24

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Psychopharmacology, Pharmacotherapy, Synaptic Dopamine Concentrations +18

A psychomotor stimulant theory of addiction.

Roy A. Wise, Michael A. Bozarth · Psychological Review · 1987 · 2.7K citations

Neuropsychology, Substance Use, Behavioral Addiction +21

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

Urban Ungerstedt · Acta Physiologica Scandinavica · 1971 · 1.9K citations

Postsynaptic Supersensitivity, Synaptic Transmission, Neurotransmitter +21

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

Jane Stewart, Harriet de Wit, Roelof Eikelboom · Psychological Review · 1984 · 1.1K citations

Substance Abuse, Psychoactive Drug, Substance Use +14