Cellulose granuloma in the lungs of a cocaine sniffer.

Abstract

<h3>ABSTRACT</h3> Allelic exclusion is a vital mechanism for the generation of monospecificity to foreign antigens in B- and T-lymphocytes. Here we developed a high-throughput barcoded method to simultaneously analyze the VDJ recombination status of both <i>T cell receptor beta</i> alleles in hundreds of single cells using Next Generation Sequencing.