Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Manfred Gossen, Heidelberg Bujard · Proceedings of the National Academy of Sciences · 1992 · 5K citations

Life Sciences, Genetics, Molecular Biology +17

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Kevin L. Lorick, Jane P. Jensen, Shengyun Fang et al. · Proceedings of the National Academy of Sciences · 1999 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +13

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

Y Gu, Tatsuya Nakamura, Hansjüerg Alder et al. · Cell · 1992 · 834 citations

Life Sciences, Genetics, Molecular Genetics +13

ALL-1 Is a Histone Methyltransferase that Assembles a Supercomplex of Proteins Involved in Transcriptional Regulation

Tatsuya Nakamura, Toshiki Mori, Shinichiro Tada et al. · Molecular Cell · 2002 · 721 citations · Full text

Life Sciences, Genetics, Molecular Biology +11

An Mll–AF9 Fusion Gene Made by Homologous Recombination Causes Acute Leukemia in Chimeric Mice: A Method to Create Fusion Oncogenes

Javier Corral, Isabelle Lavenir, Helen Impey et al. · Cell · 1996 · 533 citations · Full text

Medicine, Genetics, Molecular Biology +14