Isolation and structure of a new phenoxazine antibiotic, exfoliazone, produced by Streptomyces exfoliatus.

Abstract

During the course of our screening program for new antibiotics active against Valsa ceratosperma, the causative fungus of the apple canker disease, we found that Streptomyces exfoliatus produced a new phenoxazine antibiotic, exfoliazone (I). In this paper, we report the isolation and structure of I. S. exfoliatus BT-38, which was isolated from Matsumoto city, Nagano Prefecture, Japan, was cultivated at 27C in a 60-liter jar fermenter