Failure to detect <i>Chlamydia pneumoniae</i> in brain tissues of Alzheimer’s disease

Abstract

Chlamydia pneumoniae , a human respiratory pathogen, has recently been reported to be associated with atherosclerosis and coronary heart disease.1,2 Balin et al. has reported detection of this organism by PCR, immunocytochemistry (ICC), and electron microscopy in the brain tissues of AD in 17 of 19 patients.3 However, Gieffers et al. failed to detect C. pneumoniae by PCR in brain tissues of 20 patients with AD.4 …