Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenin-induced inflammation: Effect of non-steroidal anti-inflammatory drugs

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects

Carlo Patrono, Giovanni Ciabattoni, E Pinca et al. · Thrombosis Research · 1980 · 648 citations

Medicine, Hematology, Pharmacology +12

Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid.

Jack Y. Vanderhoek, Robert W. Bryant, Jennifer M. Bailey · Journal of Biological Chemistry · 1980 · 326 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation

G.A. Higgs, Kenneth E. Eakins, Kenneth G. Mugridge et al. · European Journal of Pharmacology · 1980 · 244 citations

Life Sciences, Immunology, Pharmacology +15