Concepedia

The practical synthesis of RNA fragments in the solid phase approach

Hiroshi Tanimura, Tetsuya Fukazawa, Mitsuo Sekine, Tsujiaki Hata, J. William Efcavitch, Gerald Zon

Tetrahedron Letters · 1988 · 31 citations · 8 references

DOIFull text

Open access

Concepts

Abstract

The combined use of the 2′-tetrahydropyran-4-yl(Thp group and 5′-9-phenylxanthen-9-yl(Pix) group or (4-methoxy)phenylxanthen-9-yl(Mox) group gave satisfactory results in the solid phasesynthesis of medium sized RNA fragments.

References

8

Polymer support oligonucleotide synthesis XVIII<sup>1.2)</sup>: use of<i>β</i>-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

N. D. SINHA, J. Biernat, J. F. A. McManus et al. · Nucleic Acids Research · 1984 · 848 citations · Full text

, , +16

Polymer-supported RNA synthesis and its application to test the nearest-neighbor model for duplex stability

Ryszard Kierzek, Marvin H. Caruthers, Carl E. Longfellow et al. · Biochemistry · 1986 · 131 citations

, , +14

Action of acid on oligoribonucleotide phosphotriester intermediates. Effect of released vicinal hydroxy functions

Colin B. Reese, Philip A. Skone · Nucleic Acids Research · 1985 · 66 citations

, , +12

Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

Chris Christodoulou, Sudhir Agrawal, Michael J. Gait · Tetrahedron Letters · 1986 · 35 citations

, , +9

The 9-(4-Octadecyloxyphenylxanthen)-9-yl-Group. A new Acid-labile Hydroxyl Protective Group and Its Application in the Preparative Reverse-phase Chromatographic Separation of Oligoribonucleotides.

Marek Kwiatkowski, Jyoti Chattopadhyaya, Jon Songstad et al. · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1984 · 23 citations · Full text

, , +11