Early Onset of Lipid Peroxidation after Human Traumatic Brain Injury: A Fatal Limitation for the Free Radical Scavenger Pharmacological Therapy?

Abstract

On the whole, these data demonstrate the early onset of oxygen radical-mediated oxidative stress, proposing a valid explanation for the failure of clinical trials based on the administration of oxygen free radical scavenger drugs and suggesting a possible rationale for testing the efficacy of lipid peroxidation "chain breakers" in future clinical trials.