The 9<i>cis</i>,11<i>trans</i>,13<i>cis</i>Isomer of Conjugated Linolenic Acid Reduces Apolipoprotein B100 Secretion and Triacylglycerol Synthesis in HepG2 Cells

Abstract

The physiological effects of 9cis,11trans,13cis-conjugated linolenic acid (9c,11t,13c-CLNA), one of the CLNA isomers, were studied in human hepatoma HepG2 cells. 9c,11t,13c-CLNA significantly decreased apolipoprotein B100 secretion compared with alpha-linolenic acid (alpha-LNA). The uptake of (14)C-oleate into newly synthesized cellular triacylglycerol was also decreased by 9c,11t,13c-CLNA more than by alpha-LNA treatment. This is the first study to show the hypolipidemic effect of 9c,11t,13c-CLNA.