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Bone-targeting glycol and NSAIDS ester prodrugs of rhein: Synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies

Medicinal ChemistryAnti-inflammatoryPharmaceutical ScienceMedicineNsaids Ester ProdrugsOsteoarthritisPharmacological AgentHydroxyapatite AffinityPharmacotherapyAnti-cancer AgentBone-targeting GlycolPharmacologyBiomolecular Engineering