T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques - Concepedia

Concepedia

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T-cell proliferation to subinfectious SIV correlates with lack of infection after challenge of macaques

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References

1994

Year

Mario Clerici, Edward A. Clark, Patricia Polacino, I. AXBERG, LaRene Kuller, Naomi I. Casey, William R. Morton, Gene M. Shearer, Raoul Ė. Benveniste

Abstract

The inability to productively infect macaques previously exposed to subinfectious doses of SIV suggests that a T-cell-mediated response may confer long-term protection against infection, and that AIDS vaccines should be designed to optimize the cellular arm of the immune response.