BMJ · 1970 · 37 citations · 15 references
MedicineInfectious DiseasesPediatricsMucosal ImmunologyPediatric ImmunologyPediatric UrologyPediatric Urinary Tract InfectionRecurrent Urinary Tract InfectionSecretory Immunoglobulin AUrinary Tract InfectionsMucosal AntibodiesPediatric Recurrent Urinary Tract InfectionUrinary Tract Infection Pathogenesis
Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals-3.3 to 0.78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.
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