Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

Robert S. Ames, Henry M. Sarau, Johathan K. Chambers et al. · Nature · 1999 · 789 citations

Medicine, Pharmacology, Molecular Pharmacology +5

Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord

Yolaine Coulouarn, Isabelle Lihrmann, Sylvie Jégou et al. · Proceedings of the National Academy of Sciences · 1998 · 395 citations

Life Sciences, Molecular Biology, Neuroscience +8

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

Vincent Sauzeau, Erik Le Mellionnec, Jacques Bertoglio et al. · Circulation Research · 2001 · 259 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues

Mika Matsushita, Masayoshi Shichiri, Taihei Imai et al. · Journal of Hypertension · 2001 · 241 citations

Life Sciences, Nephrology, Cell Signaling +8

Differential vasoconstrictor activity of human urotensin‐II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey

Stephen A. Douglas, Anthony C. Sulpizio, Valerie Piercy et al. · British Journal of Pharmacology · 2000 · 227 citations · Full text

Life Sciences, Pharmacology, Physiology +9