Direct labeling of rat M3-muscarinic receptors by [3H]4DAMP

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.

H. N. Doods, M. J. Mathy, D. Davidesko et al. · Journal of Pharmacology and Experimental Therapeutics · 1987 · 442 citations

Medicine, Neuroscience, Pharmacology +17

A unique regulatory profile and regional distribution of [3H]pirenzepine binding in the rat provide evidence for distinct M1 and M2 muscarinic receptor subtypes

Mark Watson, Henry I. Yamamura, William R. Roeske · Life Sciences · 1983 · 295 citations

Medicine, Neuroscience, Pharmacology +15

A COMPARISON OF AFFINITY CONSTANTS FOR MUSCARINE‐SENSITIVE ACETYLCHOLINE RECEPTORS IN GUINEA‐PIG ATRIAL PACEMAKER CELLS AT 29°C AND IN ILEUM AT 29°C AND 37°C

R. B. BARLOW, K.J. BERRY, Patricia A. Glenton et al. · British Journal of Pharmacology · 1976 · 292 citations · Full text

Medicine, Biochemistry, Pharmacology +16