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Endothelial β <sub>3</sub> -Adrenoceptors Mediate Vasorelaxation of Human Coronary Microarteries Through Nitric Oxide and Endothelium-Dependent Hyperpolarization

C. Dessy, Stéphane Moniotte, Philippe Ghisdal, Xavier Havaux, Philippe Noirhomme, Jean‐Luc Balligand

Circulation · 2004 · 161 citations · 26 references

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Abstract

Beta3-adrenoceptors are expressed in the endothelium of human coronary resistance arteries and mediate adrenergic vasodilatation through both NO and vessel hyperpolarization.

References

26

Molecular Characterization of the Human β <sub>3</sub> -Adrenergic Receptor

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The Importance of the Hyperpolarizing Mechanism Increases as the Vessel Size Decreases in Endothelium-Dependent Relaxations in Rat Mesenteric Circulation

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The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

Charles Gauthier, Véronique Leblais, Lester Kobzik et al. · Journal of Clinical Investigation · 1998 · 383 citations · Full text

, , +16

Importance of endothelium-derived hyperpolarizing factor in human arteries.

Lemmy Urakami-Harasawa, Hiroaki Shimokawa, Misako Nakashima et al. · Journal of Clinical Investigation · 1997 · 332 citations · Full text

, , +14

Upregulation of β<sub>3</sub>-Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium

Stéphane Moniotte, Lester Kobzik, Olivier Féron et al. · Circulation · 2001 · 319 citations · Full text