Synthesis of pyrrolo[3,4-c]pyridine derivatives possessing an acid group and their in vitro and in vivo evaluation as aldose reductase inhibitors

Quinazolineacetic acids and related analogs as aldose reductase inhibitors

Michael S. Malamas, Jane Millen · Journal of Medicinal Chemistry · 1991 · 278 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid (zopolrestat) and congeners

Banavara L. Mylari, Eric R. Larson, Thomas A. Beyer et al. · Journal of Medicinal Chemistry · 1991 · 245 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.

David K. Wilson, Ivan Tarle, J. Mark Petrash et al. · Proceedings of the National Academy of Sciences · 1993 · 163 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Glutathione depletion in the lens of galactosemic and diabetic rats

Marjorie F. Lou, Jaime E. Dickerson, Rekha Garadi et al. · Experimental Eye Research · 1988 · 144 citations

Medicine, Biochemistry, Ophthalmology +11

N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor

Kazimir Sestanj, Francesco Bellini, Steven Fung et al. · Journal of Medicinal Chemistry · 1984 · 121 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7