Novel Benzimidazo[2,1‐<i>c</i>][1,4]thiazinone Derivatives with Potent Activity Against HSV‐1

Abstract

Abstract The synthesis of new 2‐carboxymethylsulfanylmethyl‐1 H ‐benzimidazole and 1,3‐dihydro‐4 H ‐benzo[4′,5′]imidazo[2,1‐ c ][1,4]thiazine‐4‐one‐8‐carboxylic acid derivatives was investigated. The antiviral activity of compounds 1–14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg.