The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

Establishment in culture of pluripotential cells from mouse embryos

Martin Evans, M. H. Kaufman · Nature · 1981 · 8.5K citations

Embryo Culture, Embryonic Stem Cell, Induced Pluripotent Stem Cell +6

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

Gail R. Martin · Proceedings of the National Academy of Sciences · 1981 · 5.7K citations

Early Mouse Embryos, Stem Cell Biology, Embryology +16

mRNA-Seq whole-transcriptome analysis of a single cell

Fuchou Tang, Cátálin Bárbácioru, Yangzhou Wang et al. · Nature Methods · 2009 · 3.9K citations

Single Cell Sequencing, Medicine, Single-cell Biology +9

The ground state of embryonic stem cell self-renewal

Qi‐Long Ying, Jason Wray, Jennifer Nichols et al. · Nature · 2008 · 3.5K citations · Full text

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +9

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

Jennifer Nichols, Branko Zevnik, Konstantinos Anastassiadis et al. · Cell · 1998 · 3.4K citations · Full text

Embryonic Stem Cell, Induced Pluripotent Stem Cell, Developmental Biology +10