Adventitial Myofibroblasts Contribute to Neointimal Formation in Injured Porcine Coronary Arteries

Abstract

This study demonstrates translocation of adventitial fibroblasts to neointima, their phenotypic modulation to myofibroblasts, and distinct characteristics of myofibroblasts within neointima after severe endoluminal coronary injury. These findings suggest the significance of vascular fibroblasts in the process of arterial repair.