Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

Cent Inhibition, Inhibitory Activity, Biochemistry +8

Magnesium gates glutamate-activated channels in mouse central neurones

Linda M. Nowak, Pìotr Bregestovski, Philippe Ascher et al. · Nature · 1984 · 4K citations

Glutamate-activated Channels, Neurophysiology, Physiology +5

Glycine potentiates the NMDA response in cultured mouse brain neurons

John Johnson, Philippe Ascher · Nature · 1987 · 3.1K citations

Synaptic Plasticity, Biochemistry, Neurophysiology +9

Requirement for Glycine in Activation of NMDA-Receptors Expressed in <i>Xenopus</i> Oocytes

Nancy W. Kleckner, Raymond Dingledine · Science · 1988 · 1.4K citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

Tage Honoré, S.N. Davies, Jørgen Drejer et al. · Science · 1988 · 1.2K citations

Synaptic Transmission, Neurotransmitter, Pharmacotherapy +18