Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

Iván Rodríguez, Keiko Matsuura, Christiane Ody et al. · The Journal of Experimental Medicine · 1996 · 276 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Evaluation of 18F-annexin V as a PET imaging agent in an animal model of apoptosis.

Kevin Yagle, Janet F. Eary, Jonathan F. Tait et al. · PubMed · 2005 · 159 citations

Medicine, Cell Biology, Pharmacology +14

<i>N</i>-Benzylisatin Sulfonamide Analogues as Potent Caspase-3 Inhibitors:  Synthesis, in Vitro Activity, and Molecular Modeling Studies

Wenhua Chu, Jun Zhang, Chenbo Zeng et al. · Journal of Medicinal Chemistry · 2005 · 104 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +8

Rapid induction of apoptosis in rat liver by cycloheximide.

Pierpaolo Coni, Gavino Faa, Giacomo Manenti et al. · PubMed · 1992 · 85 citations

Life Sciences, Cell Biology, Pharmacology +9

Synthesis of an Estrogen Receptor β-Selective Radioligand:  5-[¹⁸F]Fluoro-(2<i>R*</i>,3<i>S*</i>)-2,3-bis(4-hydroxyphenyl)pentanenitrile and Comparison of in Vivo Distribution with 16α-[¹⁸F]Fluoro-17β-estradiol

Jeongsoo Yoo, Carmen S. Dence, Terry L. Sharp et al. · Journal of Medicinal Chemistry · 2005 · 79 citations

Medicine, Endocrinology, Pharmacology +16