Concepedia

A microRNA gene expression signature predicts response to erlotinib in epithelial cancer cell lines and targets EMT

J L Bryant, Joel S. Britson, Justin M. Balko, Michael C. Willian, Ruben Berrocal Timmons, Andrey Frolov, Esther P. Black

British Journal of Cancer · 2011 · 78 citations · 25 references

DOIFull text

Open access

Abstract

From these data, we hypothesise that the tumour microenvironment elicits TGFβ1 and stimulates a miRNA gene expression program that induces resistance to anti-EGFR therapy and drives lung tumour cells to EMT, invasion, and metastasis.

References

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Mutations in the Epidermal Growth Factor Receptor and in KRAS Are Predictive and Prognostic Indicators in Patients With Non–Small-Cell Lung Cancer Treated With Chemotherapy Alone and in Combination With Erlotinib

David A. Eberhard, Bruce E. Johnson, Lukas C. Amler et al. · Journal of Clinical Oncology · 2005 · 1.5K citations · Full text