Functional Residual Capacity in Patients with Pulmonary Emphysema

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Article1 July 1962Functional Residual Capacity in Patients with Pulmonary EmphysemaA Comparative Study Using Gas Dilution and Plethysmographic Techniques for MeasurementJOSEPH C. ROSS, M.D., DAVID E. COPHER, B.S., JOHN D. TEAYS, M.D., THOMAS J. LORD, M.D.JOSEPH C. ROSS, M.D.Search for more papers by this author, DAVID E. COPHER, B.S.Search for more papers by this author, JOHN D. TEAYS, M.D.Search for more papers by this author, THOMAS J. LORD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-1-18 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany methods have been used to measure the functional residual capacity of the lung (FRC), some simple, others complicated and elaborate. Nevertheless, an accurate measurement of functional residual capacity in patients with pulmonary emphysema has been more difficult than expected and, as time has passed, it has become apparent that the functional residual capacity in patients with emphysema is larger than previously thought.In 1940, Darling, Cournand, and Richards (1) described the open circuit nitrogen (7-minute washout) method, now widely used, for estimating functional residual capacity, but pointed out that imperfect gas mixing in the lung could impair the accuracy...References1. DARLINGCOURNANDRICHARDS RCADW: Studies on the intrapulmonary mixture of gases. III. An open circuit method for measuring residual air. J. Clin. Invest. 19: 609, 1940. CrossrefMedlineGoogle Scholar2. HICKAMBLAIRFRAYSER JBER: An open circuit helium method for measuring functional residual capacity and defective intrapulmonary gas mixing. J. Clin. Invest. 33: 1277, 1954. CrossrefMedlineGoogle Scholar3. 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BLAIRHICKAM EJB: Quantitative study of intrapulmonary gas mixing in emphysema. Amer. J. Med. 18: 519, 1955. CrossrefMedlineGoogle Scholar23. GILSONHUGH-JONES JCP: The measurement of the total lung volume and breathing capacity. Clin. Sci. 7: 185, 1948-49. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, IndianaFrom the Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana.This work was supported in part by research grant H-4080 and in part by research grant H-6228, and with facilities provided by Cardiovascular Clinical Research Center Grant H-6308, all from the National Heart Institute, National Institutes of Health.Requests for reprints should be addressed to Joseph C. Ross, M.D., Department of Medicine, Indiana University Medical Center, 1100 West Michigan Street, Indianapolis 7, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLong-term exposure to cigarette smoke impairs lung function and increases HMGB-1 expression in miceComparison of Plethysmographic and Helium Dilution Lung VolumesHow Accurate Is Spirometry at Predicting Restrictive Pulmonary Impairment?An analysis of the relationship between airway resistance and spontaneous thoracic gas volume in asthmatic childrenRoentgenologic, physiologic and structural estimations of the total lung capacity in normal and emphysematous subjectsAirway responsiveness in chronic obstructive pulmonary diseaseDie GanzkörperplethysmographieCardiopulmonary Function in Young Smokers A Comparison of Pulmonary Function Measurements and Some Cardiopulmonary Responses to Exercise Between a Group of Young Smokers and a Comparable Group of NonsmokersRICHARD A. KRUMHOLZ, M.D., ROBERT B. CHEVALIER, M.D., JOSEPH C. ROSS, M.D. 1 July 1962Volume 57, Issue 1Page: 18-28KeywordsEmphysemaHeartLungsResearch grants Issue Published: 1 July 1962 PDF DownloadLoading ...